Ulisin A has been shown to enhance the circadian gene oscillation amplitude of human senescent cells

On December 25 , 2024 , a new study published in Nutrients found that the natural polyphenol metabolite urolithin A ( 3,8-dihydroxy-6H-dibenzopyran-6-one , UA ) can enhance the circadian gene oscillation amplitude of human senescent cells. This study used aging human embryonic lung fibroblast TIG-3 to evaluate the effect of ellagic acid and its metabolites (urolithin A , B , and C ) on the cellular clock. The study found that UA promotes the stability and deacetylation activity of the key protein SIRT1 , while accelerating the degradation of PER2 protein, and enhances the oscillation amplitude of the circadian rhythm regulatory gene BMAL1 .

This discovery reveals the application value of UA as a potential anti-aging nutritional supplement, providing theoretical support for the development of treatments to improve rhythmic dysfunction related to aging, but further animal experiments and clinical trials are still needed to verify the effectiveness and safety of UA .

Curcumin has been found to reduce thrombosis risk in Alzheimer's patients

On December 23, 2024 , a new study published in Nutrients found that curcumin can effectively inhibit platelet aggregation and reactive oxygen production caused by beta amyloid peptide ( Aβ ), thereby reducing the risk of thrombosis in patients with Alzheimer's disease ( AD ) . Research has found that curcumin effectively inhibits the platelet response to Aβ by inhibiting signaling pathways such as PKC , PI3K and MAPK , and prevents the production of reactive oxygen species induced by Aβ , thereby exerting an antioxidant effect.

Compared with traditional physiological platelet agonists (such as thrombin), curcumin selective inhibition of pathological stimulation is more significant, but further research on the transgenic mouse model of AD is needed to verify the antithrombotic potential of curcumin in vivo.